Itachi’s strange illness, which appears to be a plot device Kishimoto frequently employed to be able to eliminate well-written characters from the story, is a mystery about which nothing is known. Itachi’s death was reportedly prolonged only by willpower since he wanted Sasuke to be the one to take his life. It is thought that he suffered from the same respiratory condition that killed Kimimaro.
What illness did Itachi Uchiha have in Naruto?
Itachi Uchiha’s sickness was formally acknowledged to be terminal in Naruto Chapter 401. It was revealed that he wanted to die at Sasuke’s hands and that he was only able to survive long enough via sheer resolve. Otherwise, he would have passed away from it pretty quickly. Itachi was one of the most powerful characters in the series, thus his Chakra undoubtedly helped, but his willpower played a major role as well. We may now describe the ailment he had to you since we have put this to rest. Or—can we?
Sadly, we are unable. In particular, even after all these years, we still don’t know a single thing regarding Itachi Uchiha’s ailment.
How did Itachi Uchiha die in Naruto?
Sasuke establishes Team Hebi, a tiny elite crew, to track down and assassinate Itachi after killing Orochimaru. When Konohagakure learned of Sasuke’s scheme, he began dispatching a team to assassinate Itachi, comprised of Kakashi, Sakura, Sai, Yamato, Naruto, Shino Aburame, Kiba Inuzuka and his dog Akamaru. They would also discover Sasuke that way, who they wish to return to Konohagakure.
Itachi is the main goal of both factions’ attempts to assassinate him, but Akatsuki learned of this plot as well, so Pain gave the order to stop Sasuke from approaching Itachi because he was too significant to Akatsuki.
Tobi explains to Sasuke that his brother was working with the ANBU to inform the Uchiha family of the plans the Konoha government had. Contrary to what happened in actuality, Itachi informed the Third Hokage of the Uchiha clan’s objectives. According to Tobi, Itachi had to witness a horrifying battle scenario during the Third Shinobi World War when he was just four years old. This experience caused Itachi to despise war and violence and to always seek peace. That is why he and Tobi chose to wipe off the Uchiha family.
Then Tobi reminds Sasuke that if he had truly wanted to kill Itachi, Sasuke would not have had a chance against Itachi. Additionally, according to Tobi, Itachi only ever attempted to defend his younger brother and give him more power both before and after his death. Itachi also wanted Sasuke to be embraced by the community and celebrated as a hero after defeating him.